NameDrop-dead
OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeUnknown
StrainCanton-S-5
DescriptionDrop-dead mutants die early in adult life, displaying gross neuropathological lesions in the brain. (Buchanan and Benzer, 1993) The survival curve of drop-dead mutants is four to five times shorter than, but otherwise similar in shape to, wild-type. In flies, some genes show characteristic temporal changes in expression levels with age. Drop-dead mutants have been shown to exhibit temporal compression of this time course in the three genes tested, suggesting that drop-dead mutations may cause an acceleration of the normal aging process. (Rogina et al., 1997)
Gene FunctionUnknown.
Other PhenotypesFlies begin staggering at various times early in adult life, then die. (Buchanan, 1993)
HomologsUnknown.
Primary ReferenceRogina, B., Benzer, S., and Helfand, S. L. (1997). Drosophila drop-dead mutations accelerate the time course of age- related markers. Proc Natl Acad Sci U S A 94, 6303-6. [Abstract]
Other ReferencesBuchanan, R. L., and Benzer, S. (1993). Defective glia in the Drosophila brain degeneration mutant drop-dead. Neuron 10, 839-50. [Abstract]
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0000494
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=45844
KeywordsDrosophila, fly, melanogaster, neurons