NameNPY
OrganismRattus norvegicus
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainSprague-Dawley
DescriptionOverexpression of rat NPY under the control of its own promoter results in increased mean and maximum life-span (Michalkiewicz et al., 2003). The observed life-span extension was relatively small (p=0.059 by Wilcoxin test and p=0.05 by t-test, n=20).
Gene FunctionNeuropeptide that reduces blood pressure and anxiety.
Other PhenotypesAs compared with the nontransgenic siblings, the blood pressure of the NPY transgenic rats was significantly lower (Michalkiewicz et al., 2003). Food intake and weight were not significantly different in transgenic animals compared to controls.
HomologsM.m. NPY
H.s. NPY
Primary ReferenceMichalkiewicz, M., Knestaut, K. M., Bytchkova, E. Y., and Michalkiewicz, T. (2003). Hypotension and reduced catecholamines in neuropeptide y transgenic rats. Hypertension 41, 1056-62. [Abstract]
Other References
Relevant LinksOMIM: http://www.ncbi.nlm.nih.gov:80/entrez/dispomim.cgi?id=162640
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=24604
Keywordshormone, signaling, brain, neuron, hypertension, atherosclerosis, heart disease