OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeOverexpression
DescriptionAt 20C, overexpression of hsp-16 increases life-span by 11% (Walker and Lithgow, 2003). Life-span extension by hsp-16 reuires daf-16, suggesting that it is acting through the insulin/IGF-1 signaling pathway.
Gene FunctionMolecular chaperone.
Other PhenotypesOverexpression of hsp-16 increases thermotolerance and UV resistance but does not delay development (Walker and Lithgow, 2003).
Primary ReferenceWalker, G. A., and Lithgow, G. J. (2003). Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2, 131-39.
Other References
Relevant LinksWormBase:
Keywordsheat shock, stress resistance, worm, insulin, signaling