OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
DescriptionOverexpression of PNC1 by 5-fold increases life-span by 80% (Anderson et al., 2003). Deletion of PNC1 shortens life-span slightly.
Gene Functionpyrazinamidase/nicotinamidase
Other PhenotypesNicotinamide is a potent inhibitor of Sir2p (Bitterman et al., 2002). It is thought that PNC1 regulates longevity by altering Sir2p activity (Anderson et al., 2003).
PNC1 is required for life-span extension by calorie restriction (Anderson et al., 2003). Overexpression of PNC1 decreases rDNA silencing.
Primary ReferenceAnderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., and Sinclair, D. A. (2003). Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423, 181-5. [Abstract]
Other ReferencesBitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., and Sinclair, D. A. (2002). Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 277, 45099-107. [Abstract]
Relevant LinksSGD:
Keywordsnicotinamide, silencing, replicative capacity, caloric restriction, calorie restriction, CR, rDNA, silencing, yeast, replicative senescence, Saccharomyces, cerevisiae, metabolism, NAD