OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionMutation of daf-9 extends mean and maximum life-span at 15 degrees C by 15-75% and 28-96%, respectively (Jia et al., 2002).
Life-span extension by mutation of daf-9 is suppressed by mutation of daf-12, but not by mutation of daf-16.
Mutation of daf-3 results in a wild-type life span, but greatly extends the life-span of the long-lived daf-9 mutant.
Gene FunctionPutative cytochrome P450 hydroxlase. Genetic evidence suggests that daf-9 functions downstream of the SMAD and forkhead transcription factors (Jia et al., 2002).
Other PhenotypesDaf-9 mutants are dauer constitutive (Albert and Riddle, 1998), show a gonadal cell migration defect (Jia et al., 2002), and a post-dauer molting defect.
HomologsC.e. C34B7.3
D.m. CYP18A1
R.n. CYP2C7, CYP2D4, CYP2D18 ...
M.m. CYP2C29, CYP2C38, CYP2B19 ...
H.s. CYP2C8, CYP2C19, CYP2C18 ...
Primary ReferenceJia, K., Albert, P. S., and Riddle, D. L. (2002). DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129, 221-31. [Abstract]
Other ReferencesAlbert, P. S., and Riddle, D. L. (1988). Mutants of Caenorhabditis elegans that form dauer-like larvae. Dev Biol 126, 270-93. [Abstract]
Relevant LinksWormBase:
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism