|Aging Phenotype||Life-span extension|
|Description||Mutation of daf-9 extends mean and maximum life-span at 15 degrees C by 15-75% and 28-96%, respectively (Jia et al., 2002). |
Life-span extension by mutation of daf-9 is suppressed by mutation of daf-12, but not by mutation of daf-16.
Mutation of daf-3 results in a wild-type life span, but greatly extends the life-span of the long-lived daf-9 mutant.
|Gene Function||Putative cytochrome P450 hydroxlase. Genetic evidence suggests that daf-9 functions downstream of the SMAD and forkhead transcription factors (Jia et al., 2002).|
|Other Phenotypes||Daf-9 mutants are dauer constitutive (Albert and Riddle, 1998), show a gonadal cell migration defect (Jia et al., 2002), and a post-dauer molting defect.|
R.n. CYP2C7, CYP2D4, CYP2D18 ...
M.m. CYP2C29, CYP2C38, CYP2B19 ...
H.s. CYP2C8, CYP2C19, CYP2C18 ...
|Primary Reference||Jia, K., Albert, P. S., and Riddle, D. L. (2002). DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129, 221-31. [Abstract]|
|Other References||Albert, P. S., and Riddle, D. L. (1988). Mutants of Caenorhabditis elegans that form dauer-like larvae. Dev Biol 126, 270-93. [Abstract]|
|Relevant Links||WormBase: http://www.wormbase.org/db/gene/locus?name=daf-9|
|Keywords||Caenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism|