|Organism||Saccharomyces cerevisiae (replicative)|
|Aging Phenotype||No effect on life-span|
|Description||Deletion of SLT2 has no effect on life-span (Ray et al., 2003).|
|Gene Function||MAP kinase.|
|Other Phenotypes||Deletion of SLT2 increases rDNA silencing and rDNA recombination and decreases silencing at the telomeres and HM loci (Ray et al., 2003).|
Deletion of SLT2 results in decreased phosphorylation of Sir3p and increased rDNA recombination (Ray et al., 2003).
|Homologs||S.c. SMK1, KSS1, FUS3, HOG1|
S.p. SPM1, SPK1, STY1, CDC2
H.s. MAPK7, MAPK3, MAPK1, MAPK14, MAPK11, ...
M.m. MAPK7, MAPK3, MAPK1, MAPK14, MAPK11, ...
R.n. MAPK3, MAPK1, MAPK14, MAPK12, MAPK13, ...
D.m. RL, P38B, MPK2, P38C, CDK5
C.e. MPK-1, C05D10.2
|Primary Reference||Ray, A., Hector, R. E., Roy, N., Song, J., Berkner, K. L., and Runge, K. W. (2003). Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan. Nat Genet Published online 17 March 2003.|
|Relevant Links||SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=HOG1|
|Keywords||silencing, signaling, chromatin, telomeres, rDNA, sterility, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae|