NameSLT2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainW303
DescriptionDeletion of SLT2 has no effect on life-span (Ray et al., 2003).
Gene FunctionMAP kinase.
Other PhenotypesDeletion of SLT2 increases rDNA silencing and rDNA recombination and decreases silencing at the telomeres and HM loci (Ray et al., 2003).
Deletion of SLT2 results in decreased phosphorylation of Sir3p and increased rDNA recombination (Ray et al., 2003).
HomologsS.c. SMK1, KSS1, FUS3, HOG1
S.p. SPM1, SPK1, STY1, CDC2
H.s. MAPK7, MAPK3, MAPK1, MAPK14, MAPK11, ...
M.m. MAPK7, MAPK3, MAPK1, MAPK14, MAPK11, ...
R.n. MAPK3, MAPK1, MAPK14, MAPK12, MAPK13, ...
D.m. RL, P38B, MPK2, P38C, CDK5
C.e. MPK-1, C05D10.2
Primary ReferenceRay, A., Hector, R. E., Roy, N., Song, J., Berkner, K. L., and Runge, K. W. (2003). Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan. Nat Genet Published online 17 March 2003.
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=HOG1
Keywordssilencing, signaling, chromatin, telomeres, rDNA, sterility, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae