OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion of SRS2 shortens life-span by approximately 60% (McVey et al., 2001).
Overexpression of SGS1 increased the maximum, but not mean, life-span of an SRS2 mutant (Mankouri et al., 2002)
Gene FunctionDNA helicase
Other PhenotypesDeletion of SRS2 is synthetically lethal in combination with deletion of SGS1 (McVey et al., 2001).
Primary ReferenceMcVey, M., Kaeberlein, M., Tissenbaum, H. A., and Guarente, L. (2001). The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157, 1531-42. [Abstract]
Other ReferencesMankouri, H. W., Craig, T. J., and Morgan, A. (2002). SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. Nucleic Acids Res 30, 1103-13. [Abstract]
Relevant LinksSGD:
KeywordsDNA damage, rDNA, recombination, cell cycle, DNA, yeast, replicative senescence, Saccharomyces, cerevisiae