InterventionRetinoic acid
Alternate Name
OrganismHomo sapiens (cell culture)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainOral keratinocytes
DescriptionWhen proliferating oral keratinocytes were cultured in medium containing 1 nM of all-trans retinoic acid (RA), the in vitro life-span of the cells was increased 1.5- to 1.8-fold compared to the vehicle control and the replicative senescence of the cells was significantly inhibited (You et al., 2000).
Gene Function
Other PhenotypesThe protein level of cellular p16(INK4A) in the RA-treated oral keratinocytes was gradually but significantly enhanced by an increased PDL number; however, the level was significantly lower than that of the vehicle control at all of the same PDL numbers. In contrast, the telomerase activity was maintained in oral keratinocytes with increasing PDL numbers induced by RA treatment (You et al., 2000).
Homologs
Primary ReferenceYou, Y. O., Lee, G., and Min, B. M. (2000). Retinoic acid extends the in vitro life span of normal human oral keratinocytes by decreasing p16(INK4A) expression and maintaining telomerase activity. Biochem Biophys Res Commun 268, 268-74. [Abstract]
Other References
Relevant Links
Keywordscell culture, replicative life span, human, senescence