OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeRecessive
DescriptionDeletion of CTF4 results in an approximately 75% reduction in mean life-span (Hoopes et al., 2002).
Gene FunctionDNA polymerase alpha binding protein involved in regulating replication initiation
Other Phenotypes
Primary ReferenceHoopes, L. L., Budd, M., Choe, W., Weitao, T., and Campbell, J. L. (2002). Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22, 4136-46. [Abstract]
Other References
Relevant LinksSGD:
KeywordsDNA damage, rDNA, recombination, replication, stalled replication fork, replication fork block, nucleolus cell cycle, DNA, yeast, replicative senescence, Saccharomyces, cerevisiae