NameRAD27
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainSS111
DescriptionDeletion of RAD27 results in an approximately 60% reduction in mean life-span (Hoopes et al., 2002).
Gene Function5' to 3' exonuclease required for Okazaki fragment processing
Other Phenotypes
Homologs
Primary ReferenceHoopes, L. L., Budd, M., Choe, W., Weitao, T., and Campbell, J. L. (2002). Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22, 4136-46. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=rad27
KeywordsDNA damage, rDNA, recombination, replication, stalled replication fork, replication fork block, nucleolus cell cycle, DNA, yeast, replicative senescence, Saccharomyces, cerevisiae