NamePOL1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainSS111
DescriptionMutation of POL1 results in a 20-60% reduction in mean life-span (Hoopes et al., 2002).
Gene FunctionDNA polymerase I alpha subunit p180
Other Phenotypes
HomologsS.p. POL1
R.n. POLA
M.m. POLA
H.s. POLA
D.m. POLA
Primary ReferenceHoopes, L. L., Budd, M., Choe, W., Weitao, T., and Campbell, J. L. (2002). Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22, 4136-46. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=pol1
KeywordsDNA damage, rDNA, recombination, replication, stalled replication fork, replication fork block, nucleolus cell cycle, DNA, yeast, replicative senescence, Saccharomyces, cerevisiae