OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainW303, SS111, 7585-2-2
DescriptionThree different alleles of DNA2 (dna2-1, dna2-2, and dna2-20) resulted in a significant shortening of life-span up to 85% (Hoopes et al., 2002).
Mutation of DNA2 further shortens the already short life-span of an SGS1 mutant.
Overexpression of SIR2 or deletion of FOB1 partially suppresses the short life-span of DNA2 mutants.
Gene FunctionDNA replication helicase
Other PhenotypesShort-lived DNA2 mutants show some pheotypes of premature aging, including sterility and nucleolar fragmentation (Hoopes et al., 2002).
HomologsS.p. DNA2, SPAC16C9.06C
M.m. IGHMBP2, RENT1 ...
H.s. IGHMBP2, DNA2L, RENT1 ...
D.m. UPF1
S.c. NAM7, YKL017C ...
C.e. SMG-2
Primary ReferenceHoopes, L. L., Budd, M., Choe, W., Weitao, T., and Campbell, J. L. (2002). Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22, 4136-46. [Abstract]
Other References
Relevant LinksSGD:
KeywordsDNA damage, rDNA, recombination, replication, stalled replication fork, replication fork block, nucleolus cell cycle, DNA, yeast, replicative senescence, Saccharomyces, cerevisiae