OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
DescriptionOverexpression of NPT1 extrends life-span by approximately 30% (Anderson et al., 2002). Life-span extension by increased dosage of NPT1 requires SIR2.
Deletion of NPT1 has been reported to have no effect on life-span in PSY316 (Lin et al., 2000).
Gene FunctionNicotinate phosphoribosyltransferase. Involved in NAD biosynthesis.
Other PhenotypesNPT1 is required for life span extension by caloric restriction (Lin et al., 2000).
HomologsS.p. Spac1486.06
C.e. Y94H6A.148.P
Primary ReferenceAnderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Cohen, H., Lin, S. S., Manchester, J. K., Gordon, J. I., and Sinclair, D. A. (2002). Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Bio [Abstract]
Other ReferencesS. J. Lin, P. A. Defossez, L. Guarente, Requirement of NAD and Lin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Relevant LinksSGD:
Keywordscaloric restriction, metabolism, replicative senescence, Saccharomyces, cerevisiae, yeast, nicotinamide adenine ribonucleotide