NameBCY1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainSP1
DescriptionDeletion of BCY1 results in a shortened life-span (Sun et al., 1994).
Gene FunctionRegulatory subunit of protein kinase A (PKA)
Other PhenotypesMutation of BCY1 results in increased PKA activity.
HomologsS.p. CGS1
R.n. PRKAR2A, PRKAR1B, PRKAR1A ...
H.s. PRKAR2A, PRKAR2B, PRKAR1A ...
C.e. KIN-2
M.m. PRKAR2A, PRKAR1B ...
D.m. PKA-R1
Primary ReferenceSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=bcy1
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence