|Organism||Saccharomyces cerevisiae (replicative)|
|Aging Phenotype||Shortened life-span|
|Description||Deletion of BCY1 results in a shortened life-span (Sun et al., 1994).|
|Gene Function||Regulatory subunit of protein kinase A (PKA)|
|Other Phenotypes||Mutation of BCY1 results in increased PKA activity.|
R.n. PRKAR2A, PRKAR1B, PRKAR1A ...
H.s. PRKAR2A, PRKAR2B, PRKAR1A ...
M.m. PRKAR2A, PRKAR1B ...
|Primary Reference||Sun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45. [Abstract]|
|Relevant Links||SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=bcy1|
|Keywords||yeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence|