OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeRecessive
DescriptionTransient inactivation of CDC7 resulted in a shortened life-span (Jazwinski et al., 1989)
Gene FunctionRequired for intitiation of DNA replication.
Other PhenotypesThe CDC7 gene plays a role in silencing (Axelrod and Rine, 1991), and RAS2 modulates the activity of CDC7.
HomologsS.p. HSK1, SPO4
H.s. CDC7
M.m. CDC7
Primary ReferenceJazwinski, S. M., Egilmez, N. K., and Chen, J. B. (1989). Replication control and cellular life span. Exp Gerontol 24, 423-36. [Abstract]
Other ReferencesAxelrod, A., and Rine, J. (1991). A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol Cell Biol 11, 1080-91. [Abstract]
Relevant LinksSGD:
Keywordssilencing, yeast, replicative life-span