NameTPK2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainSGY446
DescriptionDeletion of TPK2 in a tpk1 tpk3 double mutant background extends life-span by approximately 25% (Lin et al., 2000).
Gene FunctionProtein kinase A catalytic subunit.
Other PhenotypesMutation of TPK2 in a tpk1 tpk3 background decreases PKA activity.
HomologsS.c. TPK1, TPK3
S.p. PKA1
C.e. KIN-1
D.m. PKA-C, PKA-C3 ...
R.n. PRKACA ...
M.m. PRKACB, PRKACA ...
H.s. PRKACA, PRKACB ...
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other References
Relevant LinksYPD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=tpk2
Keywordscaloric restriction, metabolism, signaling, cell cycle, replicative senescence, Saccharomyces, cerevisiae, yeast