NameSNF4
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainS288C
DescriptionDeletion of SNF4 results in a 10-20% increase in replicative life-span (Ashrafi et al., 2000).
Gene FunctionActivating subunit for Snf1p
Other Phenotypes
HomologsS.p. SPAC1556.08C
H.s. PRKAG2, PRKAG1, PRKAG3
R.n. PRKAG1
M.m. PRKAG1
Primary ReferenceAshrafi, K., Lin, S. S., Manchester, J. K., and Gordon, J. I. (2000). Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14, 1872-85. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=snf4
Keywordsmetabolism, kinase, signaling, yeast, replicative senescence, Saccharomyces, cerevisiae