Nameegl-4
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainN2
DescriptionMutation of egl-4 increases life-span by approximately 55% (Hirose et al, 2003). Life-span extension by mutation of egl-4 is suppressed by daf-16.
Gene FunctioncGMP-dependent protein kinase
Other PhenotypesMutation of egl-4 results in normal morphology and development, however egl-4 animals are almost twice as big as normal and have weak egg-laying defects (Hirose et al., 2003).
HomologsM.m. PRKG1, PRKG2 ...
D.m. PKG21D, FOR, PKA-C3 ...
H.s. PRKG1, PRKG2, PRKX, PRKACA ...
R.n. PRKG2, PRKACA ...
C.e. KIN-1
Primary ReferenceHirose, T., Nakano, Y., Nagamatsu, Y., Misumi, T., Ohta, H., and Ohshima, Y. (2003). Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C. elegans. Development 130, 1089-99. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=egl-4
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176991
Keywordsbody size, reproduction, fertility, cell size