InterventionSodium borate
Alternate NameDietary boron
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionAdding excess dietary boron during the adult stage decreased the median life-span by 69% at 0.01 M sodium borate and by 21% at 0.001 M sodium borate. Lower concentrations gave small but significant increases in life-span. Supplementing a very low boron diet with 0.00025 M sodium borate improved life-span by 9.5% (Massie, 1994).
Gene Function
Other PhenotypesTotal boron concentrations in Drosophila changed during development and aging. The highest concentration of boron was found during the egg stage, followed by a decline during the larval stages. Newly emerged flies contained 35.5 ppm boron. During the adult stage the boron concentration increased by 52% by 9 weeks of age (Massie, 1994).
Primary ReferenceMassie, H. R. (1994). Effect of dietary boron on the aging process. Environ Health Perspect 102 Suppl 7, 45-8. [Abstract]
Other References
Relevant Links
Keywordsnutrition, dietary supplementation