InterventionVitamin E
Alternate Namealpha-tocopherol
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN2
DescriptionTreatment with 200 micrograms/ml vitamin E significantly prolonged C. elegans survival (17-23%) when added from hatching to day 3, while continuous exposure, either at hatching or from 4 days prior to hatching, had little additional effect. Treatment with 100 or 400 micrograms/ml vitamin E did not significantly affect life-span (Harrington and Harley, 1988).
In a more recent study, it was found that treatment with alpha-tocopherol acetate had no effect on mean or maximum life-span in worms (Adachi and Ishii, 2000).
Gene Function
Other PhenotypesAll treatments with 200 micrograms/ml vitamin E moderately reduced fecundity (total progeny) and increased the mean day of reproduction (Harrington and Harley, 1988).
Addition of vitamin E to the diet has been shown to increase life-span in the fruit fly Zaprionus paravittiger (Kakkar et al., 1996) and the rotifers Asplanchna brightwelli (Sawada and Enesco, 1984) and Philodina (Enesco and Verdone-Smith, 1980).
Dietary supplementation with vitamin E had no effect on life-span in mice (Morley and Trainor, 2001).
Homologs
Primary ReferenceHarrington, L. A., and Harley, C. B. (1988). Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech Ageing Dev 43, 71-8. [Abstract]
Other ReferencesAdachi, H., and Ishii, N. (2000). Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 55, B280-5. [Abstract]
Enesco, H. E., and Verdone-Smith, C. (1980). alpha-Tocopherol increases lifespan in the rotifer Philodina. Exp Gerontol 15, 335-8. [Abstract]
Kakkar, R., Bains, J. S., and Sharma, S. P. (1996). Effect of vitamin E on life span, malondialdehyde content and antioxidant enzymes in aging Zaprionus paravittiger. Gerontology 42, 312-21. [Abstract]
Morley, A. A., and Trainor, K. J. (2001). Lack of an effect of vitamin E on lifespan of mice. Biogerontology 2, 109-12. [Abstract]
Sawada, M., and Enesco, H. E. (1984). Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli. Exp Gerontol 19, 179-83. [Abstract]
Relevant Links
Keywordsnematode, antioxidant, oxidative stress, dietary supplementation