OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion of DNL4 does not affect life span (Kaeberlein et al., 1999).
Gene FunctionDNA ligase IV
Other PhenotypesDNL4 mutants are defective for non-homologous end-joining (Wilson et al., 1997).
HomologsS.c. CDC9
S.p. lig4, Spbc713.06
C.e. CO7H6.1, C29A12.3
D.m. CG12176, CG5602, CG17227
M.m. LIG1, LIG3
H.s. LIG1, LIG3, LIG4
Primary ReferenceKaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Other ReferencesWilson, T. E., Grawunder, U., and Lieber, M. R. (1997). Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388, 495-8. [Abstract]
Relevant LinksSGD:
KeywordsDNA damage, Non-homologous end-joining, replicative senescence, Saccharomyces, cerevisiae, yeast, NHEJ