Interventiondeprenyl
Alternate Name
OrganismRattus norvegicus
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainWistar
DescriptionLong-term administration of the monoamine oxidase inhibitor (-)-deprenyl (0.5 mg/Kg) for up to 20 months significantly increased mortality in the male Wistar rat (Gallagher et al., 1998). The increased mortality was not related to dietary intake or body weight of the rats. This is of interest in the light of recent evidence that (-)-deprenyl increases mortality in humans.
Gene FunctionMAO B (monoamine oxidase) inhibitor
Other PhenotypesIn a separate study, deprenyl was found to increase longevity in male Fischer rats (Kitani et al., 1993).
Similar treatments have been found to increase life-span in mice, dogs, and hamsters. However, it should also be noted there are a number of reports of failure of deprenyl treatment to extend life-span and shortening of lifespan by deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
Homologs
Primary ReferenceGallagher, I. M., Clow, A., and Glover, V. (1998). Long-term administration of (-)-deprenyl increases mortality in male Wistar rats. J Neural Transm Suppl 52, 315-20. [Abstract]
Other ReferencesKitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]
Kitani, K., Kanai, S., Sato, Y., Ohta, M., Ivy, G. O., and Carrillo, M. C. (1993). Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence. Life Sci 52, 281-8. [Abstract]
Relevant Links
Keywordsdeprenyl, selegiline, selegeline, Rattus norvegicus, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral