InterventionVitamin E
Alternate Namealpha-tocopherol
OrganismMus musculus
Aging PhenotypeNo effect on life-span
Allele TypeN/A
StrainUnknown
DescriptionThree groups of mice were exposed throughout life, from the time of conception until death, to 20, 40 and 400 mg/kg of vitamin E in the diet. No effect on life-span was observed and the median life-spans in the three groups were 804, 830 and 801 days, respectively (Morley and Trainor, 2001).
Gene Function
Other PhenotypesAddition of Vitamin E to the diet has been shown to increase life-span in the fruit fly Zaprionus paravittiger (Kakkar et al., 1996) and the rotifers Asplanchna brightwelli (Sawada and Enesco, 1984) and Philodina (Enesco and Verdone-Smith, 1980).
Treatment with alpha-tocopherol acetate had no effect on life-span in C. elegans (Adachi and Ishii, 2000).
Homologs
Primary ReferenceMorley, A. A., and Trainor, K. J. (2001). Lack of an effect of vitamin E on lifespan of mice. Biogerontology 2, 109-12. [Abstract]
Other ReferencesSawada, M., and Enesco, H. E. (1984). Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli. Exp Gerontol 19, 179-83. [Abstract]
Kakkar, R., Bains, J. S., and Sharma, S. P. (1996). Effect of vitamin E on life span, malondialdehyde content and antioxidant enzymes in aging Zaprionus paravittiger. Gerontology 42, 312-21. [Abstract]
Enesco, H. E., and Verdone-Smith, C. (1980). alpha-Tocopherol increases lifespan in the rotifer Philodina. Exp Gerontol 15, 335-8. [Abstract]
Adachi, H., and Ishii, N. (2000). Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 55, B280-5. [Abstract]
Relevant Links
Keywordsantioxidant, oxidative stress, dietary supplementation