Interventiondeprenyl
Alternate Name
OrganismDrosophila melanogaster
Aging PhenotypeNo effect on life-span
Allele TypeN/A
StrainOregon-R
DescriptionAdditon of 0.8 ng/fly/day deprenyl to a sucrose-based diet resulted in no significant effect on life-span (Jordens et al., 1999).
Gene FunctionMAO B (monoamine oxidase) inhibitor
Other PhenotypesLife-span reduction due to galactose feeding is partially suppressed by supplementation with (R)-deprenyl or (R)-N-(2-heptyl)-N-methylpropargylamine (Jordens et al., 1999).
Similar treatments have been found to increase life-span in mice, rats, dogs, and hamsters. However, it should also be noted there are a number of reports of failure of (-)deprenyl treatment to extend life-span and shortening of lifespan by (-)deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
Homologs
Primary ReferenceJordens, R. G., Berry, M. D., Gillott, C., and Boulton, A. A. (1999). Prolongation of life in an experimental model of aging in Drosophila melanogaster. Neurochem Res 24, 227-33. [Abstract]
Other ReferencesKitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]
Relevant Links
Keywordsselegiline, selegeline, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral