|Aging Phenotype||No effect on life-span|
|Description||Additon of 0.8 ng/fly/day deprenyl to a sucrose-based diet resulted in no significant effect on life-span (Jordens et al., 1999).|
|Gene Function||MAO B (monoamine oxidase) inhibitor|
|Other Phenotypes||Life-span reduction due to galactose feeding is partially suppressed by supplementation with (R)-deprenyl or (R)-N-(2-heptyl)-N-methylpropargylamine (Jordens et al., 1999).|
Similar treatments have been found to increase life-span in mice, rats, dogs, and hamsters. However, it should also be noted there are a number of reports of failure of (-)deprenyl treatment to extend life-span and shortening of lifespan by (-)deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
|Primary Reference||Jordens, R. G., Berry, M. D., Gillott, C., and Boulton, A. A. (1999). Prolongation of life in an experimental model of aging in Drosophila melanogaster. Neurochem Res 24, 227-33. [Abstract]|
|Other References||Kitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]|
|Keywords||selegiline, selegeline, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral|