InterventionHuman Growth Hormone Therapy
Alternate Name
OrganismHomo sapiens
Aging PhenotypeN/A
Allele TypeN/A
DescriptionSupplementation with human growth hormone (HGH) has been suggested as an anti-aging therapy. However, there is no valid scientific that HGH supplementation slows aging in people, and HGH supplementation has failed to extend life-span in rats and mice (Kalu et al., 1998).
Gene FunctionGrowth hormone.
Other PhenotypesSerum HGH levels decline with age in humans and rodents. Several genetic mutations that decrease serum GH or IGF-1 levels have been found to extend life-span in rodents (see GH, GHR, Ghrhr, IGF-1R, Pit1, or Prop1).
Primary Reference
Other ReferencesOlshansky, S. J., Hayflick, L., and Carnes, B. A. (2002). No truth to the fountain of youth. Sci Am 286, 92-5. [Abstract]
Kalu, D. N., Orhii, P. B., Chen, C., Lee, D. Y., Hubbard, G. B., Lee, S., and Olatunji-Bello, Y. (1998). Aged-rodent models of long-term growth hormone therapy: lack of deleterious effect on longevity, J Gerontol A Biol Sci Med Sci 53, B452-63. [Abstract]
Relevant Links
Keywordshormonal, signaling, dwarf, pituitary,