OrganismMesocricetus auratus
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionUnder conditions of constant darkness, mutants homozygous for the tau mutation live approximately 16% longer than wild-type animals (Oklejewicz and Daan, 2002).
Gene Function
Other PhenotypesThe single-gene mutation tau in the Syrian hamster shortens the circadian period by about 20% in the homozygous mutant and simultaneously increases the mass-specific metabolic rate by about 20% (Oklejewicz and Daan, 2002). Male and female wild-type hamsters were heavier than homozygote mutants throughout the entire life span, and heterozygous mutants had intermediate weights. There was no correlation between body mass and life-span, and the causes of the extended life-span in tau mutant hamsters remain unresolved.
Primary ReferenceOklejewicz, M., and Daan, S. (2002). Enhanced longevity in tau mutant Syrian hamsters, Mesocricetus auratus. J Biol Rhythms 17, 210-6. [Abstract]
Other References
Relevant Links
Keywordscircadian clock, photoperiod, rhythmic behaviors, clk