Interventionalpha-phenyl-N-t-butyl-nitrone
Alternate NamePBN
OrganismMusca domestica
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainUnknown
DescriptionPBN failed to extend the life-span of houseflies and was toxic at higher doses (Dubey et al., 1995).
Gene FunctionNitrones are free radical traps, but it has been suggested that the neuroprotective and anti-aging activities of nitrones do not result from mass action free radical quelling activity (Floyd et al. 2002).
Other PhenotypesPBN causes a decrease in protein carbonyl content in the gerbil brain cortex (Dubey et al., 1995).
PBN has been reported to extend life-span in mice and to extend the replicative life-span of human cells in vitro.
Homologs
Primary ReferenceDubey, A., Forster, M. J., and Sohal, R. S. (1995). Effect of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone on protein oxidation and life span. Arch Biochem Biophys 324, 249-54. [Abstract]
Other ReferencesFloyd, R. A., Hensley, K., Forster, M. J., Kelleher-Andersson, J. A., and Wood, P. L. (2002). Nitrones, their value as therapeutics and probes to understand aging. Mech Ageing Dev 123, 1021-31. [Abstract]
Relevant Links
KeywordsReactive oxygen species, oxygen free radicals, neurodegeneration, neuroinflamation, oxidative stress, spin-trap CPI-1429, spin-trap