InterventionButylated hydroxy anisole
Alternate Name
OrganismZaprionus paravittiger
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionDietary supplementation with 5, 10, or 25 mM butylated hydroxy anisole (BHA) resulted in a significant extension of mean and maxiumum life-span, up to 27% (Bains et al., 1997). BHA concentrations of 50 mM or higher were toxic and shortened life-span.
Gene FunctionAntioxidant.
Other PhenotypesThe total developmental period was delayed by 7.2%, and egg-laying rate was reduced by 19.7% on BHA feeding (Bains et al., 1997).
Primary ReferenceBains, J. S., Kakkar, R., and Sharma, S. P. (1997). Increased longevity, reduced fecundity, and delayed development in fruitfly (Zaprionus paravittiger) fed on butylated hydroxy anisole. Proc Soc Exp Biol Med 215, 237-42. [Abstract]
Other References
Relevant Links
Keywordsantioxidant, oxidative stress, dietary supplementation, fruitfly, reproduction, fertility