InterventionPropyl gallate
Alternate Name
OrganismZaprionus paravittiger
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainUnknown
DescriptionZaprionus paravittiger fed on propyl gallate (PG) supplemented diet (2.5, 25 and 250 micrograms/ml) showed an increase in life-span (Bains et al., 1996). Further increase in PG concentration (2500, 5000 and 7500 micrograms/ml) accelerated the mortality rate.
Gene FunctionAntioxidant. Superoxide dismutase mimetic (Reddan et al., 2003).
Other PhenotypesPG feeding caused a significant increase in catalase and glutathione reductase activities in both the sexes (Bains et al., 1996).
Homologs
Primary ReferenceBains, J. S., Kakkar, R., and Sharma, S. P. (1996). Gender specific alterations in antioxidant status of aging Zaprionus paravittiger fed on propyl gallate. Biochem Mol Biol Int 40, 731-40. [Abstract]
Other ReferencesReddan, J. R., Giblin, F. J., Sevilla, M., Padgaonkar, V., Dziedzic, D. C., Leverenz, V. R., Misra, I. C., Chang, J. S., and Pena, J. T. (2003). Propyl gallate is a superoxide dismutase mimic and protects cultured lens epithelial cells from H2O2 insult. E [Abstract]
Relevant Links
Keywordsantioxidant, oxidative stress, dietary supplementation, fruitfly