InterventionSodium hypophosphite
Alternate Name
OrganismZaprionus paravittiger
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionDietary supplementation with 1 uM to 1 mM sodium hypophosphite extended median and maximum life-spans in both male and female animals (Wadhwa et al., 1986). Higher levels of sodium hypophosphite increased mortality and shortened life-span.
Gene FunctionAntioxidant free radical scavenger.
Other PhenotypesSodium hypophosphite (SHP) supplementation is associated with reduced body weight (Wadhwa and Sharma, 1987), decreased lipid peroxide levels as measured by malondialdehyde content (Wadhwa et al., 1986) and increased catalase activity (Wadhwa, 1987). SHP supplementation caused depressed ATPase activity in both the sexes in comparison to the normal group. However, the rate of age-related decline in ATPase activity was lowered considerably in the SHP fed group (Wadhwa and Sharma, 1989).
Primary ReferenceWadhwa, R., Rai, N., and Sharma, S. P. (1986). Life span studies in Zaprionus paravittiger with sodium hypophosphite feeding. Gerontology 32, 141-7. [Abstract]
Other ReferencesWadhwa, R., and Sharma, S. P. (1987). Studies on catalase in ageing Zaprionus paravittiger (Diptera) with special reference to an antioxidant feeding. Mech Ageing Dev 40, 139-47. [Abstract]
Wadhwa, R. (1987). An antioxidant-induced life table modification and life-span prolongation in Zaprionus paravittiger (Diptera). Arch Gerontol Geriatr 6, 101-6. [Abstract]
Wadhwa, R., and Sharma, S. P. (1989). Effect of sodium hypophosphite feeding on adenosine triphosphatase activity in ageing Zaprionus paravittiger (Diptera). Gerontology 35, 14-8. [Abstract]
Relevant Links
Keywordsantioxidant, oxidative stress, dietary supplementation, fruitfly