InterventionVitamin E
Alternate Namealpha-tocopherol
OrganismZaprionus paravittiger
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionZaprionus paravittiger fed with vitamin E supplemented diet (1, 5 and 10 micrograms/ml) showed an increase in median and maximum life-spans. Vitamin E supplemented at higher concentrations increased mortality rate and shortened life-span (Kakkar et al., 1996).
Gene Function
Other PhenotypesFemales exhibited longer life-span as compared to males.
Vitamin E feeding caused a significant decrease in malondialdehyde and increase in catalase and peroxidase activities (Kakkar et al., 1996).
Addition of Vitamin E to the diet has also been shown to extend life-span in the rotifers Asplanchna brightwelli (Sawada and Enesco, 1984) and Philodina (Enesco and Verdone-Smith, 1980).
Dietary supplementation with vitamin E had no effect on life-span in mice (Morley and Trainor, 2001) or C. elegans (Adachi and Ishii, 2000)..
Primary ReferenceKakkar, R., Bains, J. S., and Sharma, S. P. (1996). Effect of vitamin E on life span, malondialdehyde content and antioxidant enzymes in aging Zaprionus paravittiger. Gerontology 42, 312-21. [Abstract]
Other ReferencesSawada, M., and Enesco, H. E. (1984). Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli. Exp Gerontol 19, 179-83. [Abstract]
Adachi, H., and Ishii, N. (2000). Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 55, B280-5. [Abstract]
Morley, A. A., and Trainor, K. J. (2001). Lack of an effect of vitamin E on lifespan of mice. Biogerontology 2, 109-12. [Abstract]
Enesco, H. E., and Verdone-Smith, C. (1980). alpha-Tocopherol increases lifespan in the rotifer Philodina. Exp Gerontol 15, 335-8. [Abstract]
Relevant Links
Keywordsantioxidant, fruitfly, oxidative stress, dietary supplementation