InterventionNordihydroguaiaretic acid
Alternate NameNDGA
OrganismAedes aegypti
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionAdministration of nordihydroguaiaretic acid (NDGA), a potent reducing agent, to the diet of Aedes aegypti mosquitos extended mean life-span by 42-64% (Richie et al., 1986). The most effective doses were 0.001% for females and 0.005% for males.
Gene FunctionReducing agent.
Other PhenotypesLife-span extension by NDGA ewas dependent on the age when feeding was initiated, since only biosynthetically active larvae and young adults were responsive (Richie et al., 1986).
Primary ReferenceRichie, J. P., Jr., Mills, B. J., and Lang, C. A. (1986). Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc Soc Exp Biol Med 183, 81-5. [Abstract]
Other References
Relevant Links
Keywordsantioxidant, free radicals, free radical theory of aging, mitochondria, reduction, oxidation