OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function extends life span up to 50% (Apfeld and Kenyon 1999).
Gene FunctionNot cloned.
Other PhenotypesMutants are dauer defective, chemotaxis defective, osmotic aviodance (osm), males mate poorly and mutants are dye filling defective (Perkins et al., 1986). Mutants have defective sheath cells causing the amphid and phasmids pores to be closed.
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesPerkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract]
Relevant LinksWormBase;class=Locus
KeywordsCaenorhabditis, elegans, worm, dauer, neurons