InterventionMethionine
Alternate Name
OrganismZaprionus paravittiger
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainUnknown
DescriptionThe median and maximum life-spans of both sexes of the fruit fly Zaprionus paravittiger increased with methionine (100 mM) feeding (Sharma et al., 1995).
Gene FunctionL-methionine is an essential amino acid.
Other PhenotypesMethionine supplementation was accompanied by higher catalase and peroxidase enzyme activities. The lipid peroxide level as measured by malondialdehyde content and the inorganic peroxides showed an increase with age and a decrease in methionine-fed insects (Sharma et al., 1995).
Restriction of dietary methionine extends life-span in rats (Orentreich et al., 1993).
Supplemented dietary methionine decreased life-span in mice (Massie and Aiello, 1984).
Homologs
Primary ReferenceSharma, S. P., Sharma, M., and Kakkar, R. (1995). Methionine-induced alterations in the life span, antioxidant enzymes, and peroxide levels in aging Zaprionus paravittiger (Diptera). Gerontology 41, 86-93. [Abstract]
Other ReferencesOrentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr 123, 269-74. [Abstract]
Massie, H. R., and Aiello, V. R. (1984). The effect of dietary methionine on the copper content of tissues and survival of young and old mice. Exp Gerontol 19, 393-9. [Abstract]
Relevant Links
Keywordsantioxidant, oxidative stress, calorie restriction, caloric, diet, nutrition, amino acid, protein,