|Aging Phenotype||Life-span extension|
|Description||The median and maximum life-spans of both sexes of the fruit fly Zaprionus paravittiger increased with methionine (100 mM) feeding (Sharma et al., 1995).|
|Gene Function||L-methionine is an essential amino acid.|
|Other Phenotypes||Methionine supplementation was accompanied by higher catalase and peroxidase enzyme activities. The lipid peroxide level as measured by malondialdehyde content and the inorganic peroxides showed an increase with age and a decrease in methionine-fed insects (Sharma et al., 1995).|
Restriction of dietary methionine extends life-span in rats (Orentreich et al., 1993).
Supplemented dietary methionine decreased life-span in mice (Massie and Aiello, 1984).
|Primary Reference||Sharma, S. P., Sharma, M., and Kakkar, R. (1995). Methionine-induced alterations in the life span, antioxidant enzymes, and peroxide levels in aging Zaprionus paravittiger (Diptera). Gerontology 41, 86-93. [Abstract]|
|Other References||Orentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr 123, 269-74. [Abstract]|
Massie, H. R., and Aiello, V. R. (1984). The effect of dietary methionine on the copper content of tissues and survival of young and old mice. Exp Gerontol 19, 393-9. [Abstract]
|Keywords||antioxidant, oxidative stress, calorie restriction, caloric, diet, nutrition, amino acid, protein,|