InterventionMethionine
Alternate Name
OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainC57BL/6J
DescriptionThe life-span of old mice was unchanged by feeding 0.05M methionine. Young mice, however, experienced a 16.9% decrease in their average life-span and a decreased maximum life-span when given supplemental methionine (Massie and Aiello, 1984).
Gene FunctionL-methionine is an essential amino acid.
Other PhenotypesOld mice given 0.05M methionine in their drinking water for 42 days had lower brain copper concentrations. The decrease in liver, kidney, and heart copper was not significant when compared to unsupplemented controls (Massie and Aiello, 1984).
Restriction of dietary methionine extends life-span in rats (Orentreich et al., 1993).
Supplemented dietary methionine increased life-span in the fruit fly Zaprionus paravittiger (Sharma et al., 1995).
Homologs
Primary ReferenceMassie, H. R., and Aiello, V. R. (1984). The effect of dietary methionine on the copper content of tissues and survival of young and old mice. Exp Gerontol 19, 393-9. [Abstract]
Other ReferencesOrentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr 123, 269-74. [Abstract]
Sharma, S. P., Sharma, M., and Kakkar, R. (1995). Methionine-induced alterations in the life span, antioxidant enzymes, and peroxide levels in aging Zaprionus paravittiger (Diptera). Gerontology 41, 86-93. [Abstract]
Relevant Links
Keywordscalorie restriction, caloric, diet, nutrition, amino acid, protein,