OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeSemi-dominant
StrainBristol N2
DescriptionSemi-dominant mutation increases life span by 10-15% (Malone et al., 1996).
Gene FunctionNot cloned.
Other Phenotypesdaf-28 mutant is dauer constitutive (Malone and Thomas, 1994).
Primary ReferenceMalone, E. A., Inoue, T., and Thomas, J. H. (1996). Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143, 1193-205. [Abstract]
Other ReferencesMalone, E. A., and Thomas, J. H. (1994). A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. Genetics 136, 879-86. [Abstract]
Relevant LinksWormBase:
Keywordsdauer, Caenorhabditis, elegans, worm