NamePUF4
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainBKx1-14c
DescriptionDeletion of YGL023 has no effect on life-span in either a uth4-14c (C-terminal truncation) or UTH4 background. However, YGL023 is required for life-span extension by the semi-dominant Sir4-42 allele in the uth4-14c background (Kennedy et al., 1997).
Gene FunctionPutative mRNA binding protein.
Other PhenotypesYGL023 is required for nucleolar relocalization of Sir3p in a Sir4-42 background (Kennedy et al., 1997)
HomologsS.p. SPAC6G9.14, SPAC4G8.03C, SPAC4G9.05
D.m. pumilio
S.c. MPT5, JSN1
C.e. FBF-2
Primary ReferenceKennedy, B. K., Gotta, M., Sinclair, D. A., Mills, K., McNabb, D. S., Murthy, M., Pak, S. M., Laroche, T., Gasser, S. M., and Guarente, L. (1997). Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life sp [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=YGL023
Keywordssilencing, chromatin, telomeres, rDNA, yeast, replicative senescence, Saccharomyces, cerevisiae, mRNA binding