OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionMutation of daf-2 increases life span more than 100% (Kenyon et al., 1993). Mutation of daf-2 in combination with a mutation of daf-12 results in a nearly 300% increase in life span. (Larsen et al., 1995).
Gene FunctionInsulin-like / IGF-1 tyrosine kinase receptor (Kimura et al., 1997).
Other Phenotypesdaf-2 mutants are dauer constitutive (Riddle et al., 1981) and display reduced brood size (Tissenbaum and Ruvkun 1998; Gems et al. 1998). daf-2 mutants synergize with germ line ablation for life span (Hsin and Kenyon 1999) and also show synergy with clk-1 mutants for life span (Lakowski et al. 1996). All phenotypes of daf-2 are suppressed by mutation of daf-16 (Kenyon et al. 1993; Dormand et al. 1995; Larsen et al. 1995; Gems et al. 1998; Tissenbaum and Ruvkun 1998).
Mutation of daf-2 also results in increased expression of sod-3, the Mn-superoxide dismutase (Honda and Honda, 1999).
HomologsS.c. CDC28, PHO85, CLA4, PKC1, SKM1, IPL1 ...
S.p. shk2, cdc7, pck2, Spac890.03, byr1, pef1 ...
C.e. Y55D5A.d, Y55D5A.c, kin-22, abl-1, C24G6.2, cam-1 ...
D.m. InR, sev, CG8250, Alk, CG1061, Ret ...
R.n. Insr, Rn.10957, Ntrk3, Rn.9797, Ntrk2, Ntrk1 ...
M.m. Igfr1r, Insr, Insrr, Ros1, Fgfr1, Frk ...
Primary ReferenceKenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-4. [Abstract]
Other ReferencesGems, D., Sutton, A. J., Sundermeyer, M. L., Albert, P. S., King, K. V., Edgley, M. L., Larsen, P. L., and Riddle, D. L. (1998). Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis e [Abstract]
Honda, Y., and Honda, S. (1999). The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. Faseb J 13, 1385-93. [Abstract]
Hsin, H., and Kenyon, C. (1999). Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-6. [Abstract]
Kimura, K. D., Tissenbaum, H. A., Liu, Y., and Ruvkun, G. (1997). daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-6. [Abstract]
Larsen, P. L., Albert, P. S., and Riddle, D. L. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-83. [Abstract]
Riddle, D. L., Swanson, M. M., and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-71. [Abstract]
Tissenbaum, H. A., and Ruvkun, G. (1998). An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717. [Abstract]
Vanfleteren, J. R. (1993). Oxidative stress and aging in Caenorhabditis elegans. Biochem. J. 292, 605-608. [Abstract]
Vanfleteren, J. R., and de Vreese, A. (1995). The geronotogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J 9, 1355-1361. [Abstract]
Relevant LinksWormBase:
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, caloric restriction, oxidative stress