OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function increases life span up to 50% (Apfeld and Kenyon 1999).
Gene FunctionRFX-type transcription factor (Swoboda et al. 2000).
Other PhenotypesMutants are dauer constitutive, dye-filling defective, and lack sensory cilia (Riddle et al., 1981; Collet et al., 1998).
HomologsS.c. RFX1
S.p. sak1
D.m. RFX
M.m. RFX2, RFX1, RFX3
H.s. RFX2, RFX3, RFX1
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesCollet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E., and Herman, R. K. (1998). Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. Genetics 148, 187-200. [Abstract]
Riddle, D. L., Swanson, M. M., and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-71. [Abstract]
Swoboda, P., Adler, H. T., and Thomas, J. H. (2000). The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Mol Cell 5, 411-21. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, transcription factor, dauer, neurons