OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRNAi
DescriptionRNAi of scl-1 results in a slight but reproducible decrease in life-span, similar to the effect of mutation in daf-16 (Ookuma et al., 2003). RNAi of scl-1 prevents the life-span extension associated with mutation of daf-2 or age-1.
Gene FunctionUnknown. Putative secretory protein.
Other PhenotypesScl-1 has a Daf-16 binding element in its promoter and it suggested to be a direct target for transcriptional activation by Daf-16 (Ookuma et al., 2003).
Scl-1 mRNA is highly expressed in daf-2 or age-1 mutants, lowly expressed in wild-type N2 and not detectable in daf-16 mutants (Ookuma et al., 2003).
RNAi of scl-1 causes heat shock and UV sensitivity (Ookuma et al., 2003).
HomologsH.s. TPX1 (CRISP2), CRISP3, GLIPR1, AEGL1 (CRISP1)
C.e. F48E8.1
M.m AEG1, TPX1, AEG2
S.c. PRY3, PRY2, PRY1
Primary ReferenceOokuma, S., Fukuda, M., and Nishida, E. (2003). Identification of a daf-16 transcription target gene, scl-1, that regulates longevity and stress resistance in caenorhabditis elegans. Curr Biol 13, 427-31.
Other References
Relevant LinksWormBase:
KeywordsCaenorhabditis, worm, stress response, dauer, temperature, radiation,