Namebeach1
OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeDeletion
Strainunknown
DescriptionMutation of beach1 results in a 40-45% decrease in mean life-span (Finley et al., 2003).
Gene FunctionIntracellular protein transport, lysosomal transport.
Other PhenotypesBeach1 mutants display an age-related neurodegenerative phenotype with reduced CNS size and altered morphology (Finley et al., 2003). Mutation of beach1 also results in an accumulation of insoluble ubiquinated proteins and amyloid precursor-like proteins along with an increase in neuronal apoptosis (Finley et al., 2003).
HomologsS.c. BPH1
M.m. CHS1, FAN,
H.s. LRBA, CHS1, FAN
Primary ReferenceFinley, K. D., Edeen, P. T., Cumming, R. C., Mardahl-Dumesnil, M. D., Taylor, B. J., Rodriguez, M. H., Hwang, C. E., Benedetti, M., and McKeown, M. (2003). blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J [Abstract]
Other References
Relevant LinksFlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0043362
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=33819
KeywordsAPPL, aggregates, ubiquinated, bchs, thioflavine S., neurodegenerative