NameCOQ3
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainDBY746
DescriptionDeletion of COQ3 decreases stationary phase survival (Fabrizio et al., 2003).
Gene FunctionHexaprenyldihydroxybenzoate methyltransferase. Involved in ubiquinone metabolism.
Other PhenotypesNull mutant is respiration deficient and senstive to hydrogen peroxide.
HomologsS.p. COQ3
H.s. COQ3
R.n COQ3
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=coq3
Keywordsrespiration, metabolism, Saccharomyces, cerevisiae, yeast, stationary phase, oxidative stress, mitochondria, uncouple