OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
Descriptiondaf-18 mutants can partially suppress the life span extension of age-1 and daf-2 mutants (Larsen et al., 1995).
Gene FunctionPTEN phosphatase.
Other Phenotypesdaf-18 mutants are defective for dauer formation; forms some dauer-like larvae when starved (Dorman et al. 1995; Larsen et al. 1995)
HomologsS.c. TEP1, CDC14
S.p. Spbc609.02p
C.e. F46F11.3, T12B3.D
D.m. PTEN, CG5671, CG1107
R.n. Rn.2218, Rn.11012
H.s. PTEN, TPTE, GAK, FLJ10923
Primary ReferenceLarsen, P. L., Albert, P. S., and Riddle, D. L. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-83. [Abstract]
Other ReferencesDorman, J. B., Albinder, B., Shroyer, T., and Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-406. [Abstract]
Relevant LinksWormBase:;class=Locus
Keywordsmetabolism, insulin, signaling, dauer, Caenorhabditis, elegans, worm, dauer