InterventionAntimycin A
Alternate Name
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainDBY746
DescriptionIncubation in the presense of 1 uM anitmycin A decreases stationary phase survival (Fabrizio et al., 2003).
Gene FunctionAntimycin A is a respiratory inhibitor.
Other PhenotypesTreatment of C. elegans with antimycin A extends life-span in that organism (Dillin et al., 2002).
Homologs
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46 [Abstract]
Other ReferencesDillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-401. [Abstract]
Relevant Links
Keywordsrespiration, metabolism, Saccharomyces, cerevisiae, yeast, stationary phase, oxidative stress, mitochondria, uncouple