InterventionFCCP
Alternate NameTrifluorocarbonylcyanide phenylhydrazone
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainDBY746
DescriptionIncubation in the presense of 4 uM FCCP increases stationary phase survival after 12 days (Fabrizio et al., 2003).
Gene FunctionFCCP is a respiratory inhibitor that reduces superoxide production.
Other Phenotypes
Homologs
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46 [Abstract]
Fabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46 [Abstract]
Other References
Relevant Links
Keywordsrespiration, metabolism, Saccharomyces, cerevisiae, yeast, stationary phase, oxidative stress, mitochondria, uncouple