NameMSN4
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainDBY746
DescriptionSimultaneous deletion of MSN2 and MSN4 has no effect on stationary phase survival, but prevents increased survival associated with RAS2 deletion (Fabrizio et al., 2003).
Gene FunctionTranscriptional activator that mediates stress-induced gene expression; repressed by cAMP-PKA pathway (Smith et al., 1998)
Other PhenotypesDeletion of MSN2 and MSN4 has no effect on replicative life-span and does not prevent life-span extension by calorie restriction (Lin et al., 2000) or by high osmolarity (Kaeberlein et al., 2002).
Homologs
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Fabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Other ReferencesKaeberlein, M., Andalis, A. A., Fink, G. R., and Guarente, L. (2002). High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction. Mol Cell Biol 22, 8056-66. [Abstract]
Lin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8 [Abstract]
Smith, A., Ward, M. P., and Garrett, S. (1998). Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. Embo J 17, 3556-64 [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=mpt4
Keywordsoxidative stress, heat shock, signaling, transcription factor, yeast, replicative senescence, stationary phase survival, Saccharomyces, cerevisiae