NameRAS2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainSP-1
DescriptionRAS2 deletion caused a 23% decrease in mean and a 30% decrease in maximum replicative life-span (Sun et al., 1994).
Overexpression of RAS2 caused a 43% increase in mean and 18% increase in maximum replicative life-span (Sun et al., 1994).
Gene FunctionGTP-binding protein involved in regulation of the cAMP pathway
Other PhenotypesDeletion of RAS2 increases stationary phase survival by about 2-fold (Fabrizio et al., 2003).
HomologsS.c. Ras1p, Rsr1p, Ypt1p
S.p. Ras1p, Rhb1p, Ypt1p
C.e .C27B7.8, RAS-2, LET-60
D.m. R, RIC, RAS85D
R.n. RN.10007, RN.11271, HRAS
M.m. KRAS2, NRAS, HRAS1
H.s. TC21, KRAS2, NRAS
Primary ReferenceSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45 [Abstract]
Other ReferencesFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ras2
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence