NameRAS2
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainSP-1, DBY746
DescriptionDeletion of RAS2 increases stationary phase survival by about 2-fold (Fabrizio et al., 2003). Increased stationary phase survival requires MSN2 and MSN4.
Gene FunctionGTP-binding protein involved in regulation of the cAMP pathway
Other PhenotypesOverexpression of RAS2 caused a 43% increase in mean and 18% increase in maximum replicative life-span (Sun et al., 1994).
RAS2 deletion caused a 23% decrease in mean and a 30% decrease in maximum replicative life-span (Sun et al., 1994).
HomologsS.c. Ras1p, Rsr1p, Ypt1p
S.p. Ras1p, Rhb1p, Ypt1p
C.e .C27B7.8, RAS-2, LET-60
D.m. R, RIC, RAS85D
R.n. RN.10007, RN.11271, HRAS
M.m. KRAS2, NRAS, HRAS1
H.s. TC21, KRAS2, NRAS
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Other ReferencesSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45 [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ras2
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence