OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeOverexpression
DescriptionOverexpression of RAS1 has no effect on life-span (Sun et al., 1994).
Deletion of RAS1 results in a 23% increase in mean and 29% increase in maximum replicative life-span (Sun et al., 1994).
Gene FunctionGTP-binding protein involved in regulation of the cAMP pathway.
Other PhenotypesDeletion of RAS1 slightly shortened stationary phase survival (Fabrizio et al., 2003).
HomologsS.c. Ras2p, Rsr1p, Ypt1p
S.p. Ras1p, Rhb1p, Ypt2p
C.e. C27B7.8, RAS-2, LET-60
D.m. R, RIC, RAS85D
R.n. RN.10007, RN.11271, HRAS
H.s. TC21, KRAS2, NRAS
Primary ReferenceSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45. [Abstract]
Other ReferencesFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46 [Abstract]
Relevant LinksSGD:
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence