OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion of RAS1 slightly shortened stationary phase survival (Fabrizio et al., 2003).
Gene FunctionGTP-binding protein involved in regulation of the cAMP pathway.
Other PhenotypesDeletion of RAS1 results in a 23% increase in mean and 29% increase in maximum replicative life-span (Sun et al., 1994).
Overexpression of RAS1 has no effect on replicative life-span (Sun et al., 1994).
HomologsS.c. Ras2p, Rsr1p, Ypt1p
S.p. Ras1p, Rhb1p, Ypt2p
C.e. C27B7.8, RAS-2, LET-60
D.m. R, RIC, RAS85D
R.n. RN.10007, RN.11271, HRAS
H.s. TC21, KRAS2, NRAS
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46 [Abstract]
Other ReferencesSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45. [Abstract]
Relevant LinksSGD:
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, stationary phase survival, oxidative stress, mitochondria, respiration, electron transport, reactive oxygen species, ROS, antioxidant, replicative senescence